An evaluation of concentrations of styrene-7,8-oxide in rats and humans resulting from exposure to styrene or styrene-7,8-oxide and potential genotoxicity
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- 作者：Johannes Georg Filsera ; johannes.filser@helmholtz-muenchen.de" class="auth_mail" title="E-mail the corresponding author ; Heinz-Peter Gelbkeb
- 关键词：ACBSO ; lifetime average concentration of SO in venous blood ; AUC ; area under a concentration-time curve ; AUCST ; area under the concentration-time curve of ST in venous blood ; AUCSO ; area under the concentration-time curve of SO in venous blood ; BW ; body weight ; CmaxSO ; maximum (peak) concentration of SO in venous blood ; FPG ; formamidopyrimidine DNA glycosylase ; LEC ; lowest effective SO concentration resulting in a genotoxic/mutagenic effect ; OML ; Overall Migration Limit in the EU ; maximum permit
- 刊名：Toxicology Letters
- 出版年：2016
- 出版时间：15 April 2016
- 年：2016
- 卷：247
- 期：Complete
- 页码：11-28
- 全文大小：1428 K
文摘
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Genotoxic risk of styrene-7,8-oxide (SO) after oral styrene (ST) intake was evaluated.
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Study was based on published results on inhalation genotoxicity of ST or SO in rats.
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A physiological toxicokinetic model predicted blood burdens of SO in rats and humans.
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Genotoxic risk of SO was linked to the SO blood burden.
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A genotoxic risk of SO for humans resulting from ST from food containers is excluded.