The PDRG1 is an oncogene in lung cancer cells, promoting radioresistance via the ATM-P53 signaling pathway

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• 作者：Zheng Tao¹ ; ^{114015615@qq.com" class="auth_mail" title="E-mail the corresponding author} ; Shaomu Chen² ; ^{chenshaomu@suda.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Guocai Mao ^{844023585@qq.com" class="auth_mail" title="E-mail the corresponding author} ; Haifeng Xia ^{1036095832@qq.com" class="auth_mail" title="E-mail the corresponding author} ; Haitao Huang ^{15312180734@163.com" class="auth_mail" title="E-mail the corresponding author} ; Haitao Ma ; ^{mahaitaosuzhou@126.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：ATM ; ataxia telangiectasia mutated ; PDRG1 ; P53 and DNA damage-regulated gene ; PDRG1i ; PDRG1 inhibition ; PDRG1o ; PDRG1 overexpression ; IR ; irradiation
• 刊名：Biomedicine & Pharmacotherapy
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：83
• 期：Complete
• 页码：1471-1477
• 全文大小：2564 K

文摘

PDRG1, is short for P53 and DNA damage-regulated gene, which have been found over 10 years. Although severe studies have described the roles of PDRG1 separately in many kinds of tumors, how to act as an oncogene are unclear. To better verify the function of PDRG1 in lung cancer, both loss-function and gain-function of PDRG1 studies based on two human lung cancer lines were performed. Following the transfection of PDRG1, both A549 and 95-D cells showed significant changes in cell viability, the expression of some protein and apoptosis, which were all implied the PDRG1 is an oncogene. Another interesting finding is PDRG1 could promote radioresistance involved the ATM-p53 signaling pathway in lung cancer. If we combine radiotherapy with gene-targeted therapy together effectively, predominant effect may be acquired, which is a huge milestone in clinical cure about lung cancer.