The p21-activated kinase, PAK2, is important in the activation of numerous pancreatic acinar cell signaling cascades and in the onset of early pancreatitis events
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- 作者：Bernardo Nuche-Berenguer ; Irene Ramos-Á ; lvarez ; R.T. Jensen ; robertj@bdg10.niddk.nih.gov" class="auth_mail" title="E-mail the corresponding author
- 关键词：CCK ; COOH-terminal octapeptide of cholecystokinin ; TPA ; 12-O-tetradecanoylphorbol-13-acetate ; PAK ; p21-activated kinases ; SFK ; Src family of kinases ; PKC ; protein kinase C ; PYK2 ; proline-rich tyrosine kinase 2 ; FAK ; focal adhesion kinase ; SHC ; Src homology 1 domain containing transforming protein ; PKD ; protein kinase D ; CAS ; Crk-associated substrate ; PI3K ; phosphatidylinositol-3-CAKβ ; cell adhesion kinase β ; PTEN ; phosphatase and tensin homolog ; Cbl ; casitas B-lineage lymphoma proto-oncogene ; RA
- 刊名：Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：1862
- 期：6
- 页码：1122-1136
- 全文大小：2005 K
文摘
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PAK2 is a mediator of CCK/TPA action upon FAKs, MAPKs and PI3K pathways.
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PAK2 mediates trypsin activation in pancreatic acini.
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CCK stimulates the proteolytic fraction of PAK2, which is involved in apoptosis.
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PAK2 mediates cell death processes in pancreatic acini-apoptosis and necrosis.
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PAK2 mediates ROS production in pancreatic acini.