Novel synthesis of tetrahydro-1H-pyrrolo[1,2-a]imidazol-2-ones via decarboxylative cyclization reaction of α-amino acids and α-ketoamides

详细信息    查看全文

• 作者：Jia-shou Wu ; ^{jsw79@tzc.edu.cn} ; Hua-jiang Jiang ; Jian-guo Yang ; Zheng-neng Jin ; Ding-ben Chen
• 关键词：α-Ketoamide ; α-Amino acid ; Azomethine ylide ; Decarboxylative cyclization ; Tetrahydro-1H-pyrrolo[1 ; 2-a]imidazol-2-ones
• 刊名：Tetrahedron Letters
• 出版年：2017
• 出版时间：8 February 2017
• 年：2017
• 卷：58
• 期：6
• 页码：546-551
• 全文大小：2156 K
• 卷排序：58

文摘

An efficient and practical approach to tetrahydro-1H-pyrrolo[1,2-a]imidazol-2-ones. Two C-N bonds are formed in one step. In most cases, high yields and perfect diastereoselectivity were obtained.