Portable, On-Demand Biomolecular Manufacturing

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• 作者：Keith Pardee¹ ; ¹⁰ ; Shimyn Slomovic² ; ¹⁰ ; Peter Q. Nguyen³ ; ¹⁰ ; Jeong Wook Lee² ; ³ ; ¹⁰ ; Nina Donghia³ ; Devin Burrill³ ; Tom Ferrante³ ; Fern R. McSorley⁴ ; Yoshikazu Furuta² ; Andyna Vernet³ ; Michael Lewandowski³ ; Christopher N. Boddy⁴ ; Neel S. Joshi³ ; ⁵ ; James J. Collins² ; ³ ; ⁶ ; ⁷ ; ⁸ ; ⁹ ; ¹¹ ; ^{jimjc@mit.edu" class="auth_mail" title="E-mail the corresponding author}
• 关键词：synthetic biology ; portable molecular manufacturing ; cell-free expression ; antimicrobial peptides ; antibody mimetic conjugates ; vaccine antigens ; violacein biosynthetic pathway ; decentralized biomanufacturing ; freeze-dried ; on-demand biosynthesis
• 刊名：Cell
• 出版年：2016
• 出版时间：22 September 2016
• 年：2016
• 卷：167
• 期：1
• 页码：248-259.e12
• 全文大小：4835 K

文摘

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d="p0010">A cell-free platform for on-site, on-demand biomolecular manufacturing

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d="p0015">Distribution and production of therapeutics and biomolecules without a cold chain

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d="p0020">Synthesis and functional validation of antimicrobial peptides and vaccines

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d="p0025">Combinatorial manufacturing of antibody mimetic conjugates and small molecules

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