AMP-activated protein kinase has diet-dependent and -independent roles in Drosophila oogenesis

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• 作者：Kaitlin M. Laws^a ; ¹ ; ^{klaws@mail.med.upenn.edu} ; Daniela Drummond-Barbosa^a ; ^b ; ^{dbarbosa@jhu.edu}
• 关键词：Diet ; AMPK ; LKB1 ; Germline stem cell ; Follicle growth ; Oogenesis ; Drosophila
• 刊名：Developmental Biology
• 出版年：2016
• 出版时间：1 December 2016
• 年：2016
• 卷：420
• 期：1
• 页码：90-99
• 全文大小：1415 K
• 卷排序：420

文摘

AMPK restricts germline stem cell (GSC) proliferation on a poor diet. AMPK inhibits vitellogenesis on a poor diet, but does not control early cyst death. AMPK in follicle cells, but not in the germline, controls follicle growth. Basal AMPK activity promotes GSC maintenance on a rich diet. AMPK has a nutrient-independent, developmental role in follicle formation.