Perforin-like protein PPLP4 is crucial for mosquito midgut infection by Plasmodium falciparum
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- 作者：Christine C. Wirtha ; 1 ; Sandra Benninka ; 1 ; Matthias Scheuermayerb ; Rainer Fischerc ; Gabriele Pradela ; c ; gabriele.pradel@molbiotech.rwth-aachen.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：IFA ; immunofluorescence assay ; MACPF ; membrane attack complex/perforin ; MBP ; maltose-binding protein ; NMS ; neutral mouse serum ; p.a. ; post-activation ; p.f. ; post-feeding ; PPLP4(&minus ; ) ; PPLP4-deficient ; RT ; room temperature ; SEM ; standard error of mean ; SMFA ; standard membrane feeding assay
- 刊名：Molecular & Biochemical Parasitology
- 出版年：2015
- 出版时间：June 2015
- 年：2015
- 卷：201
- 期：2
- 页码：90-99
- 全文大小：1799 K
文摘
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PPLP4 is expressed in female P. falciparum gametocytes and ookinetes.
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PPLP4-deficient parasites are unable to infect mosquitoes.
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PPLP4-deficient ookinetes accumulate in the mosquito midgut.