EWGWS insert in Plasmodium falciparum ookinete surface enolase is involved in binding of PWWP containing peptides: Implications to mosquito midgut invasion by the parasite
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- 作者：Debanjan Mukherjeea ; Pushpa Mishrab ; Mamata Joshib ; Prasoon Kumar Thakurc ; R.V. Hosurb ; Gotam K. Jaroria ; gkjarori@gmail.com" class="auth_mail" title="E-mail the corresponding author ; gkj@tifr.res.in" class="auth_mail" title="E-mail the corresponding author
- 关键词：P. falciparum ; Enolase ; Ookinete ; ITC ; NMR ; Molecular docking
- 刊名：Insect Biochemistry and Molecular Biology
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：68
- 期：Complete
- 页码：13-22
- 全文大小：1551 K
文摘
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Plasmodium falciparum enolase (Pfeno) has a pentapeptide insert, EWGWS, not present in host enolases.
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The EWGWS motif of Pfeno binds peptides containing the PWWP sequence.
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Plasmodium ookinete enolase may bind PWWP domain in peritrophic matrix proteins facilitating it to traverse through mosquito midgut epithelium.