A colostrum trypsin inhibitor gene expressed in the Cape fur seal mammary gland during lactation
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- 作者：Elizabeth A. Pharoa ; b ; 1 ; e.pharo@unimelb.edu.au" class="auth_mail" title="E-mail the corresponding author ; Kylie N. Canea ; b ; kylie.cane@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Julia McCoeyc ; julia.mccoey@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Ashley M. Bucklec ; ashley.buckle@monash.edu" class="auth_mail" title="E-mail the corresponding author ; W.H. Oosthuizend ; oosthuiz@environment.gov.za" class="auth_mail" title="E-mail the corresponding author ; Christophe Guinete ; guinet@cebc.cnrs.fr" class="auth_mail" title="E-mail the corresponding author ; John P.Y. Arnoulda ; b ; f ; john.arnould@deakin.edu.au" class="auth_mail" title="E-mail the corresponding author
- 关键词：AMBP ; α1-microglobulin/bikunin precursor ; APP ; amyloid (βA4) precursor protein ; CSN2 ; β-casein ; BPTI ; bovine pancreatic trypsin inhibitor ; cDNA ; DNA complementary to RNA ; CTI ; colostrum trypsin inhibitor ; Da ; Dalton ; ELP ; early lactation protein ; h ; hour ; IgG ; immunoglobulin G ; KD ; Kunitz domain ; LGB2 ; β-lactoglobulin II ; PIGT ; phosphatidyl inositol glycan ; class T ; pp ; postpartum ; PRSS1 ; protease ; serine ; 1 (trypsin 1) ; SLPI ; secretory leukocyte protease inhibitor ; SPINLW1 ; serine peptidase inh
- 刊名：Gene
- 出版年：2016
- 出版时间：1 March 2016
- 年：2016
- 卷：578
- 期：1
- 页码：7-16
- 全文大小：1770 K
文摘
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The Colostrum trypsin inhibitor (CTI) gene is expressed in the Cape fur seal mammary gland.
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CTI encodes a small glycosylated protein with a single Kunitz/bovine pancreatic trypsin inhibitor (BPTI) domain.
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Homology modelling suggests that CTI inhibits trypsin in a canonical mechanism.
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CTI may enhance pup survival by preventing the proteolysis of immunoglobulins.