Quercetin, a main flavonoid in onion, inhibits the PGF2α-induced uterine contraction in vitro and in vivo
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- 作者：Chi-Hao Wua ; wch@tmu.edu.tw" class="auth_mail" title="E-mail the corresponding author ; Tzong-Ming Shiehb ; Kai-Lee Wanga ; Tsui-Chin Huangc ; Shih-Min Hsiaa ; bryanhsia@tmu.edu.tw" class="auth_mail" title="E-mail the corresponding author
- 关键词：ANOVA ; analysis of variances ; [Ca2+]i ; intracellular calcium concentrations ; DMEM ; Dulbecco's modified Eagle's medium ; DMSO ; dimethyl sulphoxide ; EDTA ; ethylenediaminetetraacetic acid ; EGTA ; ethylene glycol bis(3-aminoethyl ether)-N ; N ; N&prime ; N&prime ; -tetraacetic acid ; Fura 2-AM ; fura-2/acetoxymethyl ester ; FP ; PGF2α receptor ; HutSMCs ; human uterine smooth muscle cells ; MLC20 ; myosin light chain ; MLCK ; myosin light chain kinase ; MLCP ; myosin light chain phosphatase ; NSAIDs ; non-steroidal anti-i
- 刊名：Journal of Functional Foods
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：19
- 期：part_PA
- 页码：495-504
- 全文大小：2342 K
文摘
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Ca2+-dependent uterine contractions were inhibited by quercetin.
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Quercetin reduced the PGF2α-elicited Ca2+ responses in human uterine smooth muscle cells.
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Quercetin was able to block Ca2+ influx through voltage-operated Ca2+ channels in plasma membrane.
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Quercetin reduces PGF2α-induced contractions in rat in vivo.