T-Type voltage-sensitive calcium channels mediate mechanically-induced intracellular calcium oscillations in osteocytes by regulating endoplasmic reticulum calcium dynamics
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- 作者：Genevieve N. Brown ; Pui L. Leong ; X. Edward Guo ; ed.guo@columbia.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：R ; endoplasmic reticulum ; VSCC ; voltage-sensitive calcium channels ; Ca2+ ; ; calcium ; SOCE ; store-operated calcium entry ; IP3 ; inositol trisphosphate
- 刊名：Bone
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：88
- 期：Complete
- 页码：56-63
- 全文大小：1361 K
文摘
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Ca2 +cyt and Ca2 +ER are observed simultaneously in single bone cells under flow.
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Ca2 + exchange between the ER and the cytosol is highly synchronized in osteocytes.
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Antagonizing T-Type VSCC in osteocytes alters Ca2 +ER dynamics and synchrony.