Targeted superparamagnetic iron oxide nanoparticles for early detection of cancer: Possibilities and challenges

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• 作者：Zahra Bakhtiary ; PharmD^a ; Amir Ata Saei ; PharmD^b ; Mohammad J. Hajipour ; PhD^c ; Mohammad Raoufi ; PhD^d ; ^f ; Ophir Vermesh ; PhD^e ; Morteza Mahmoudi ; PhD^f ; ^g ; ^h ; ^{Mahmoudi@stanford.edu" class="auth_mail" title="E-mail the corresponding author} ; ^{mahmoudi-m@tums.ac.ir" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Diagnosis ; Ligand ; Magnetic resonance imaging ; SPION ; Targeting
• 刊名：Nanomedicine: Nanotechnology, Biology and Medicine
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：12
• 期：2
• 页码：287-307
• 全文大小：2061 K

文摘

Nanomedicine, the integration of nanotechnological tools in medicine demonstrated promising potential to revolutionize the diagnosis and treatment of various human health conditions. Nanoparticles (NPs) have shown much promise in diagnostics of cancer, especially since they can accommodate targeting molecules on their surface, which search for specific tumor cell receptors upon injection into the blood stream. This concentrates the NPs in the desired tumor location. Furthermore, such receptor-specific targeting may be exploited for detection of potential metastases in an early stage. Some NPs, such as superparamagnetic iron oxide NPs (SPIONs), are also compatible with magnetic resonance imaging (MRI), which makes their clinical translation and application rather easy and accessible for tumor imaging purposes. Furthermore, multifunctional and/or theranostic NPs can be used for simultaneous imaging of cancer and drug delivery. In this review article, we will specifically focus on the application of SPIONs in early detection and imaging of major cancer types.

From the Clinical Editor

Super-paramagnetic iron oxide nanoparticles (SPIONs) have been reported by many to be useful as an MRI contrast agent in the detection of tumors. To further enhance the tumor imaging, SPIONs can be coupled with tumor targeting motifs. In this article, the authors performed a comprehensive review on the current status of using targeted SPIONS in tumor detection and also the potential hurdles to overcome.