Spectral-Domain Optical Coherence Tomography-Derived Characteristics of Bruch Membrane Opening in a Young Adult Australian Population

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• 作者：Paul Gerard Sanfilippo^a ; ^b ; ^{prseye@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Emily Huynh^a ; Seyhan Yazar^a ; Alex William Hewitt^a ; ^b ; ^c ; David Anthony Mackey^a ; ^b ; ^c
• 刊名：American Journal of Ophthalmology
• 出版年：2016
• 出版时间：May 2016
• 年：2016
• 卷：165
• 期：Complete
• 页码：154-163
• 全文大小：1492 K

文摘

To characterize and quantify Bruch membrane opening (BMO)-based optic nerve head (ONH) parameters in a large, young and healthy, predominantly white population.

Design

Cross-sectional study and reliability analysis.

Methods

The ONH of 1344 predominantly white subjects were imaged with spectral-domain optical coherence tomography (SD-OCT). A customized script, coded in Matlab, was used to manually segment and measure multiple BMO-based parameters of the ONH. Measurements were compared to those obtained with confocal scanning laser ophthalmoscopy (Heidelberg Retina Tomograph; HRT). Regression analysis was performed to assess the relationship between BMO parameters and other ocular and demographic variables.

Results

Mean BMO disc and neuroretinal rim (NRR) areas ranged from 0.94 to 4.06 mm² (mean 1.77 ± 0.38 mm²) and 0.94 to 3.99 mm² (mean 1.56 ± 0.31 mm²), respectively. When compared to the equivalent HRT measurements, SD-OCT-derived measures differed significantly for all comparable ONH parameters (P < .001). The limits of agreement computed from Bland-Altman plots comparing SD-OCT and HRT measurements showed suboptimal agreement between the techniques. Linear regression analysis demonstrated an effect of ethnicity, axial length, and refractive error on BMO-based parameters.

Conclusions

We have quantified BMO-based parameters in a large cohort of young adults using SD-OCT. These data will be informative in constructing normative profiles for clinical and research purposes in glaucoma diagnosis and management.