Discovery, structure-activity relationship studies, and anti-nociceptive effects of N-(1,2,3,4-tetrahydro-1-isoquinolinylmethyl)benzamides as novel opioid receptor agonists
Structural modification resulted in a series of μ/κ-opioid receptor agonists. Compound 46 demonstrated potent anti-nociceptive effect in B6 mice. A molecular docking of 46 predicted the potential binding site in μ-opioid receptor.