Changes in D1 but not D2 dopamine or mu-opioid receptor expression in limbic and motor structures after lateral hypothalamus electrical self-stimulation: A quantitative autoradiographic study
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- 作者：Maria J. Simona ; mjsimon@ugr.es" class="auth_mail" title="E-mail the corresponding author ; A. Higuera-Matasb ; D. Roura-Martinezb ; M. Uchab ; R. Santos-Toscanob ; C. Garcia-Lecumberrib ; E. Ambrosiob ; A. Puertoa
- 关键词：Intracranial self-stimulation (ICSS) ; Appetitive motivation ; Dopamine ; Opioids ; Quantitative autoradiography ; Rats
- 刊名：Neurobiology of Learning and Memory
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：127
- 期：Complete
- 页码：17-26
- 全文大小：1563 K
文摘
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The lateral hypothalamus supports strong intracranial self-stimulation.
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A quantitative autoradiographic Mu and DA receptor analysis was applied after ICSS.
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Ventral Pallidum, Acb-Shell and Caudate–Putamen nuclei (among others) were involved.
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D1 but not D2 or mu receptors were activated after ICSS.
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These results were interpreted in terms of a goal-directed function of ICSS-LH.