Flagellin and pilin immunization against multi-drug resistant Pseudomonas aeruginosa protects mice in the burn wound sepsis model
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- 作者：Fatemeh Korpia ; Farhad B. Hashemib ; Gholamreza Irajiana ; dr.irajian@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Mohammad Javad Fatemic ; Parisa Laghaeia ; Bahador Behrouzb ; c ; bahador.behroz3@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Pseudomonas aeruginosa ; r-b-flagellin ; r-PilA ; Immunization ; Antibody ; Burn
- 刊名：Immunology Letters
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：176
- 期：Complete
- 页码：8-17
- 全文大小：1886 K
文摘
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This is the first report of protective efficacy of “r-b-flagellin + r-PilA” against P. aeruginosa strains in the burned-mouse model.
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Active “r-b-flagellin + r-PilA” immunization yielded good humoral immune response (increase IgG1/IgG2a and IL-4/IFN-γ responses).
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Antibodies raised to “r-b-flagellin + r-PilA” were able to also increased P. aeruginosa opsonophagocytic activity.
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Using “r-b-flagellin + r-PilA” as vaccine, a high level of protection against multi-drug resistant P. aeruginosa burn infections was obtained.