Revaccination with 23-valent pneumococcal polysaccharide vaccine in the Japanese elderly is well tolerated and elicits immune responses
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- 作者：Kenji Kawakamia ; Hiroyuki Kishinob ; hiroyuki.kishino@merck.com" class="auth_mail" title="E-mail the corresponding author ; Shinichi Kanazub ; Nobuhito Toshimizub ; Kenichi Takahashib ; Tina Sterlingc ; Meihua Wangc ; Luwy Museyc
- 关键词：AE ; adverse event ; CI ; confidence interval ; GMC ; geometric mean concentration ; GMFR ; geometric mean fold rise ; GMT ; geometric mean titer ; IgG ; immunoglobulin G ; IPD ; invasive pneumococcal disease ; MOPA ; multiplexed OPA ; OPA ; opsonophagocytic killing activity ; Pn ECL ; pneumococcal electrochemiluminescence ; PCV13 ; 13-valent pneumococcal conjugate vaccine ; PPSV23 ; 23-valent pneumococcal polysaccharide vaccine
- 刊名：Vaccine
- 出版年：2016
- 出版时间：19 July 2016
- 年：2016
- 卷：34
- 期：33
- 页码：3875-3881
- 全文大小：633 K
文摘
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Serum-specific antibody concentration similar after PPSV23 primary and revaccination.
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Opsonophagocytic killing activity similar after PPSV23 primary and revaccination.
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No evidence of hyporesponsiveness after revaccination with PPSV23.
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Revaccination with PPSV23 was safe and well tolerated in the elderly.