Immunogenicity and safety of a second administration of 13-valent pneumococcal conjugate vaccine 5 years after initial vaccination in adults 50 years and older
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- 作者：Robert W. Frenck Jr.a ; Robert.Frenck@cchmc.org" class="auth_mail" title="E-mail the corresponding author ; Anne Fiquetb ; anne.fiquet@pfizer.com" class="auth_mail" title="E-mail the corresponding author ; Alejandra Gurtmanc ; alejandra.gurtman@pfizer.com" class="auth_mail" title="E-mail the corresponding author ; Martin van Cleeffd ; mvancleeff@carymedicalgroup.com" class="auth_mail" title="E-mail the corresponding author ; Matthew Davise ; mdavis@rcrclinical.com" class="auth_mail" title="E-mail the corresponding author ; John Rubinof ; jrubino@pmg-research.com" class="auth_mail" title="E-mail the corresponding author ; William Smithg ; wbsmd@noccr.com" class="auth_mail" title="E-mail the corresponding author ; Vani Sundaraiyerh ; Vani.Sundaraiyer@inventivhealth.com" class="auth_mail" title="E-mail the corresponding author ; Mohinder Sidhuc ; mohinderjitsidhu@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; Emilio A. Eminic ; 1 ; Emilio.Emini@gatesfoundation.org" class="auth_mail" title="E-mail the corresponding author ; William C. Gruberc ; bill.gruber@pfizer.com" class="auth_mail" title="E-mail the corresponding author ; Daniel A. Scottc ; dan.scott@pfizer.com" class="auth_mail" title="E-mail the corresponding author ; Beate Schmoele-Thomai ; Beate.Schmoele-Thoma@Pfizer.com" class="auth_mail" title="E-mail the corresponding author ; on behalf of the B1851020 Study Group
- 关键词：ACIP ; Advisory Committee on Immunization Practices ; AE ; adverse event ; CAPiTA ; Community-Acquired Pneumonia immunization Trial in Adults ; CI ; confidence interval ; CRM197 ; cross-reactive material 197 ; GMC ; geometric mean concentration ; GMFR ; geometric mean fold rise ; GMT ; geometric mean titer ; IgG ; immunoglobulin G ; IPD ; invasive pneumococcal disease ; OPA ; opsonophagocytic activity ; PCV13 ; 13-valent pneumococcal conjugate vaccine ; PCV ; pneumococcal conjugate vaccine ; PPSV23 ; 23-valent pneumococca
- 刊名：Vaccine
- 出版年：2016
- 出版时间：24 June 2016
- 年：2016
- 卷：34
- 期：30
- 页码：3454-3462
- 全文大小：1055 K
文摘
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Adults ≥50 years, were revaccinated with PCV13 five years after initial vaccination.
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Immune responses significantly increased from before to 1 month after revaccination.
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Immune responses were maintained or enhanced for most vaccine serotypes by revaccination.
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The safety profile after PCV13 revaccination was acceptable.