The utilization of optically-induced-dielectrophoresis (ODEP)-based virtual cell filters in a microfluidic system for continuous isolation and purification of circulating tumour cells (CTCs) based on their size characteristics

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• 作者：Wen-Pin Chou^a ; ¹Author Vitae ; Hung-Ming Wang^b ; ¹Author Vitae ; Jyun-Huan Chang^aAuthor Vitae ; Tzu-Keng Chiu^cAuthor Vitae ; Chia-Hsun Hsieh^b ; ^cAuthor Vitae ; Chia-Jung Liao^a ; ^{l329735@ms49.hinet.net}Author Vitae ; Min-Hsien Wu^a ; ^b ; ^d ; ^{mhwu@mail.cgu.edu.tw}Author Vitae
• 关键词：Optically induced dielectrophoresis (ODEP) ; Microfluidics ; Cell isolation ; Circulating tumor cells (CTCs) ; Cancer cells
• 刊名：Sensors and Actuators B: Chemical
• 出版年：2017
• 出版时间：31 March 2017
• 年：2017
• 卷：241
• 期：Complete
• 页码：245-254
• 全文大小：2292 K
• 卷排序：241

文摘

Optically induced dielectrophoresis (ODEP), and flow velocity control are integrated in a microfluidic system for cell isolation. A four-cascade cell isolation is implemented for a higher-resolution cell separation, and thus higher-purity cell isolation. The method is able to isolate cancer cells in a high cell purity manner (94.9 ± 0.3%).