Evaluation of the attenuation, immunogenicity, and efficacy of a live virus vaccine generated by codon-pair bias de-optimization of the 2009 pandemic H1N1 influenza virus, in ferrets
详细信息    查看全文
文摘

We generated a 2009 pH1N1 vaccine virus with codon pair bias de-optimized HA & NA genes.

The vaccine virus was clinically attenuated and immunogenic in a ferret model.

The vaccine virus protected ferrets from challenge with wt 2009 pH1N1 virus.

Additional de-optimization is needed to reduce vaccine virus replication in ferrets.

© 2004-2018 中国地质图书馆版权所有 京ICP备05064691号 京公网安备11010802017129号

地址:北京市海淀区学院路29号 邮编:100083

电话:办公室:(+86 10)66554848;文献借阅、咨询服务、科技查新:66554700