Discretized multi-level elution trajectory: A proof-of-concept demonstration

详细信息    查看全文

• 作者：Anton Sellberg^a ; Anders Holmqvist^a ; Fredik Magnusson^b ; Christian Andersson^c ; Bernt Nilsson^a ; ^{bernt.nilsson@chemeng.lth.se} ;
• 关键词：Chromatography ; Simulation ; Model ; Calibration ; Optimization
• 刊名：Journal of Chromatography A
• 出版年：2017
• 出版时间：20 January 2017
• 年：2017
• 卷：1481
• 期：Complete
• 页码：73-81
• 全文大小：2280 K
• 卷排序：1481

文摘

An experimental implementation of multi-level elution trajectories is presented. Linear and step gradient elution is used to calibrate the model. The elution trajectory is found by solving a dynamic optimization problem. Proof of concept is demonstrated by at-line and off-line analysis of the peaks.