Regulation of TBK1 activity by Optineurin contributes to cell cycle-dependent expression of the interferon pathway
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- 作者：Robert WeilAuthor Vitae ; Emmanuel LaplantineAuthor Vitae ; Pierre Gé ; nin ; pierre.genin@pasteur.fr" class="auth_mail" title="E-mail the corresponding authorAuthor Vitae
- 关键词：Antiviral host defence ; Innate immunity ; Cell cycle regulation ; Autophagy
- 刊名：Cytokine & Growth Factor Reviews
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：29
- 期：Complete
- 页码：23-33
- 全文大小：1944 K
文摘
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Advances in our understanding of Optineurin mechanisms of action with focus on the relationships between Optn and TBK1.
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Implication of TBK1/Optineurin axis in host defense against pathogens.
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How the antiviral immune system is controlled during the cell and the physiological consequences of this regulatory mechanism.
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Role of TBK1 in the different functions of Optn, including those related to immune responses and its associated pathologies.