纬未 T cells in infection and autoimmunity

详细信息    查看全文

• 作者：Lifei Hou ; ¹ ; ^{Lifei.Hou@childrens.harvard.edu" class="auth_mail" title="E-mail the corresponding author} ; Tian Wang ; Jiaren Sun ; ^{jisun@utmb.edu" class="auth_mail" title="E-mail the corresponding author}
• 关键词：纬未 T cells ; IL-17 ; IFN-纬 ; Infection ; Autoimmunity
• 刊名：International Immunopharmacology
• 出版年：2015
• 出版时间：October 2015
• 年：2015
• 卷：28
• 期：2
• 页码：887-891
• 全文大小：291 K

文摘

Standing at the interface of innate and adaptive immune, 纬未 T cells play important pathophysiologic roles in infection, autoimmunity, and tumorigenesis. Recent studies indicate that 纬未 T cells could be categorized into IFN-纬⁺ and IL-17⁺ subsets, both of which possess select TCR usages, bear unique surface markers and require different cytokine signaling to maintain the homeostasis. In addition, as the major innate IL-17 producers, 纬未 T cells are increasingly appreciated for their involvement in various acute infections and injuries. This review will summarize the characteristics of IFN-纬⁺ (纬未 T-IFN-纬) and IL-17⁺ 纬未 T cells (纬未T17) and discuss their distinct pathogenic functions in different disease models.