Relationship between calcium mobilization and platelet 伪- and 未-granule secretion. A role for TRPC6 in thrombin-evoked 未-granule exocytosis
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- 作者：E. Lopeza ; N. Bermejob ; A. Berna-Erroa ; N. Alonsoc ; G.M. Salidoa ; P.C. Redondoa ; J.A. Rosadoa ; jarosado@unex.es" class="auth_mail" title="E-mail the corresponding author
- 关键词：Calcium ; 伪-granules ; 未-granules ; Platelets ; Thrombin ; TRPC6
- 刊名：Archives of Biochemistry and Biophysics
- 出版年：2015
- 出版时间：1 November 2015
- 年：2015
- 卷：585
- 期：Complete
- 页码：75-81
- 全文大小：1366 K
文摘
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Activated platelets degranulate to release agents important for primary haemostasis.
Intracellular Ca2+ mobilization is essential for 伪- and 未-granule secretion.
伪-granule secretion occurs rapidly upon platelets stimulation with thrombin.
Exogenous Ca2+ entry is necessary for the exocytosis of 未-granule but not 伪-granules.
Canonical transient receptor potential-6 (TRPC6) function is important for 未-granule secretion.