Activated platelets degranulate to release agents important for primary haemostasis.
Intracellular Ca2+ mobilization is essential for 伪- and 未-granule secretion.
伪-granule secretion occurs rapidly upon platelets stimulation with thrombin.
Exogenous Ca2+ entry is necessary for the exocytosis of 未-granule but not 伪-granules.
Canonical transient receptor potential-6 (TRPC6) function is important for 未-granule secretion.