Differences in Botulinum Toxin Dosing Between Patients With Adductor Spasmodic Dysphonia and Essential Voice Tremor

详细信息    查看全文

• 作者：Diana M. Orbelo ; Joseph R. Duffy ; Becky J. Hughes Borst ; Dale Ekbom ; Nicolas E. Maragos
• 关键词：Spasmodic dysphonia ; Botulinum toxin ; Tremor ; Dystonia ; Dystonic tremor ; Essential voice tremor
• 刊名：Journal of Voice
• 出版年：January, 2014
• 年：2014
• 卷：28
• 期：1
• 页码：123-127
• 全文大小：103 K

文摘

| Figures/TablesFigures/Tables | ReferencesReferencesml version="1.0" encoding="UTF-8"?>

Summary

Objectives

To explore possible dose differences in average botulinum toxin (BTX) given to patients with adductor spasmodic dysphonia (ADSD) compared with patients with essential voice tremor (EVT).

Methods

A retrospective study compared the average BTX dose injected in equal doses to the thyroarytenoid (TA) muscles of 51 patients with ADSD with 52 patients with EVT.

Results

Those with ADSD received significantly higher total doses (6.80聽卤聽2.79 units) compared with those with EVT (5.02聽卤聽1.65 units). Dose at time of first injection, age at time of first injection, gender, year of first injection, and average time between injections were included in multivariate analysis but did not interact with total average dose findings.

Conclusions

Patients with ADSD may need relatively higher doses of BTX injections to bilateral TA muscles compared with patients with EVT.