Associations Between Socioeconomic Status and Major Complications in Type 1 Diabetes: The Pittsburgh Epidemiology of Diabetes Complication (EDC) Study

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• 作者：Aaron M. Secrest PhD^a ; Tina Costacou PhD^a ; Bruce Gutelius MD ; MPH^b ; Rachel G. Miller MS^a ; Thomas J. Songer PhD^a ; Trevor J. Orchard MD ; MMedSci^a ; ^{orchardt@edc.pitt.edu}
• 关键词：Autonomic Neuropathy ; Coronary Artery Disease ; Diabetes Complications ; End-Stage Renal Disease ; Prospective Study ; Socioeconomic Status ; Type 1 Diabetes
• 刊名：Annals of Epidemiology
• 出版年：2011
• 出版时间：May 2011
• 年：2011
• 卷：21
• 期：5
• 页码：374-381
• 全文大小：108 K

文摘

Purpose

To understand the effect of socioeconomic status (SES) on the risk of complications in type 1 diabetes (T1D), we explored the relationship between SES and major diabetes complications in a prospective, observational T1D cohort study.

Methods

Complete data were available for 317 T1D persons within 4 years of age 28 (ages 24−32) in the Pittsburgh Epidemiology of Diabetes Complications Study. Age 28 was selected to maximize income, education, and occupation potential and to minimize the effect of advanced diabetes complications on SES.

Results

The incidences over 1 to 20 years’ follow-up of end-stage renal disease and coronary artery disease were two to three times greater for T1D individuals without, compared with those with a college degree (p < .05 for both), whereas the incidence of autonomic neuropathy was significantly greater for low-income and/or nonprofessional participants (p < .05 for both). HbA_1c was inversely associated only with income level. In sex- and diabetes duration-adjusted Cox models, lower education predicted end-stage renal disease (hazard ratio [HR], 2.9; 95 % confidence interval [95 % CI], 1.1−7.7) and coronary artery disease (HR, 2.5, 95 % CI, 1.3−4.9), whereas lower income predicted autonomic neuropathy (HR, 1.7; 95 % CI, 1.0−2.9) and lower-extremity arterial disease (HR, 3.7; 95 % CI, 1.1−11.9).

Conclusions

These associations, partially mediated by clinical risk factors, suggest that lower SES T1D individuals may have poorer self-management and, thus, greater complications from diabetes.