Aspectos cronobiol¨®gicos de la obesidad y el s¨ªndrome metab¨®lico
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- 作者：Purificació ; n Gó ; mez-Abellá ; n
- 关键词：Cronobiologí ; a ; Obesidad ; Sí ; ndrome Metabó ; lico
- 刊名：Endocrinolog¨ªa y Nutrici¨®n
- 出版年：2012
- 出版时间：January, 2012
- 年：2012
- 卷：59
- 期：1
- 页码：50-61
- 全文大小：1509 K
文摘
<p>Circadian rhythms (approximately 24 h) are widely characterized at molecular level and their generation is acknowledged to originate from oscillations in expression of several clock genes and from regulation of their protein products. While general entrainment of organisms to environmental light-dark cycles is mainly achieved through the master clock of the suprachiasmatic nucleus in mammals, this molecular clockwork is functional in several organs and tissues. Some studies have suggested that disruption of the circadian system (chronodisruption (CD)) may be causal for manifestations of the metabolic syndrome. This review summarizes (1) how molecular clocks coordinate metabolism and their specific role in the adipocyte; (2) the genetic aspects of and scientific evidence for obesity as a chronobiological illness; and (3) CD and its causes and pathological consequences. Finally, ideas about use of chronobiology for the treatment of obesity are discussed.