The intracellular fate of an amphipathic pH-responsive polymer: Key characteristics towards drug delivery
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- 作者：S.A. Mercado ; C. Orellana-Tavra ; A. Chen ; N.K.H. Slater ; nkhs2@cam.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 关键词：PP-50 ; Amphipathic polymer ; Endocytosis mechanisms ; Caveolin ; Clathrin ; Macropinocytosis
- 刊名：Materials Science & Engineering C
- 出版年：2016
- 出版时间：1 December 2016
- 年：2016
- 卷：69
- 期：Complete
- 页码：1051-1057
- 全文大小：777 K
文摘
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Endocytosis mechanisms of an amphipathic biopolymer, PP-50, were evaluated in osteosarcoma cells.
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Colocalisation of PP-50 with different endolysosomal route markers was analysed.
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PP-50 relies on a combination of mechanisms rather than a single one for cell internalisation.
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PP-50 was shown to escape the endolysosomal compartment before maturation.