Cardiorenal fibrosis and dysfunction in aging: Imbalance in mediators and regulators of collagen
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- 作者：S. Jeson Sangaralinghama ; sangaralingham.jeson@mayo.edu" class="auth_mail" title="E-mail the corresponding author ; Bing H. Wangb ; Li Huangb ; Sirinart Kumfub ; Tomoko Ichikia ; Henry Krumb ; John C. Burnett Jr.a
- 关键词：Fibrosis ; Cardiorenal ; Natriuretic peptides ; Renin&ndash ; angiotensin&ndash ; aldosterone system ; Gene expression
- 刊名：Peptides
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：76
- 期：Complete
- 页码：108-114
- 全文大小：1207 K
文摘
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Experimental aging is associated with a parallel increase in cardiorenal fibrosis.
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An imbalance between the NPS, RAAS and TGF-β1 pathways favors fibrogenesis.
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Cardiorenal fibrosis is correlated with a decline in collagen degradation with aging.