15^th Annual Meeting of the Safety Pharmacology Society: Focus on traditional sensory systems

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• 作者：Icilio Cavero^a ; ^{iciliocavero@outlook.com} ; Henry Holzgrefe^b
• 关键词：α2M ; alpha2-macroglobuline ; ARMD ; age-related macular degeneration ; AMP ; adenosine monophosphate ; ATP ; adenosine triphosphate ; ASR ; acoustic startle response ; BM ; basilar membrane ; cAMP ; cyclic adenosine monophosphate ; CBER ; Center for Biologics Evaluation and Research ; CCCRC ; Connecticut chemosensory clinical research center ; CIPN ; chemotherapy-induced peripheral neurotoxicity ; CSERP ; chemosensory event-related potentials ; CRO ; contract research organizations ; CSF ; cerebrospinal fluid ; DN4 ; dou
• 刊名：Journal of Pharmacological and Toxicological Methods
• 出版年：2017
• 出版时间：January-February 2017
• 年：2017
• 卷：83
• 期：Complete
• 页码：55-71
• 全文大小：512 K
• 卷排序：83

文摘

This report summarizes and comments key talks on the five traditional senses (ear, vestibular system, vision, taste, olfaction, and touch) which were delivered during the 2015 Annual Meeting of the Safety Pharmacology (SP) Society.Areas coveredThe functional observational battery (FOB) can detect major candidate drug liabilities only on ear, touch and vision. Anatomy, physiology, pharmacology, and pathology notions on each sensory system introduce speaker talks. Techniques for evaluating drug effects on hearing functions are reviewed. Nonclinical approaches to assess vestibular toxicity leading to balance deficits are presented. Retinal explants studied with multielectrode arrays allow the identification of drug liability sites on the retina. Routinely performed Safety Pharmacology assays are not powered to address candidate drug-induced disturbances on taste and smell. This weakness needs correction since unintended pharmacological impairment of these sensorial functions may have serious health consequences. Neuropathy produced by chemotherapeutic agents may cause multiple sensorial perception distortions.ConclusionsSafety Pharmacology studies should ensure the safety of any candidate drug on the five sensorial systems.