Delayed application of the anesthetic propofol contrasts the neurotoxic effects of kainate on rat organotypic spinal slice cultures
详细信息 查看全文
- 作者：Dzejla Bajrektarevic ; Andrea Nistri ; nistri@sissa.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：Spinal cord injury ; Glutamate receptors ; GABAA and glycine receptors ; General anesthetic ; Neuroprotection ; Motoneuron
- 刊名：Neurotoxicology
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：54
- 期：Complete
- 页码：1-10
- 全文大小：2456 K
文摘
- •
Delayed application of propofol blocked excitotoxic spinal neurodegeneration in vitro.
- •
Propofol strongly protected motoneurons and premotoneurons.
- •
Propofol protection was prevented by bicuculline and unaffected by strychnine.
- •
Bicuculline and strychnine alone were not toxic, yet intensified excitotoxicity.
- •
Delayed application of general anesthetics may limit acute spinal damage.