Domoic acid disrupts the activity and connectivity of neuronal networks in organotypic brain slice cultures
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- 作者：E.M. Hiolskia ; 1 ; S. Itob ; 1 ; J.M. Beggsc ; K.A. Lefebvred ; A.M. Litkeb ; ; D.R. Smitha ; drsmith@ucsc.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Domoic acid ; Multielectrode recording ; Developmental neurotoxicity ; Organotypic brain slice culture
- 刊名：Neurotoxicology
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：56
- 期：Complete
- 页码：215-224
- 全文大小：2672 K
文摘
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Domoic acid is a neurotoxin produced by algae during harmful algal blooms.
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Domoic acid altered the activity pattern and connectivity density of neural networks.
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Domoic acid silenced a subset of putatively identified inhibitory fast-spiking neurons.
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Findings suggest domoic acid exposure may alter neurological function without clinical symptoms.