Mapping the Accessible Conformational Landscape of an Insect Carboxylesterase Using Conformational Ensemble Analysis and Kinetic Crystallography

详细信息    查看全文

• 作者：Galen J. Correy¹ ; Paul D. Carr¹ ; Tamara Meirelles¹ ; Peter D. Mabbitt¹ ; Nicholas J. Fraser¹ ; Martin Weik² ; Colin J. Jackson¹ ; ^{colin.jackson@anu.edu.au" class="auth_mail" title="E-mail the corresponding author}
• 刊名：Structure
• 出版年：2016
• 出版时间：7 June 2016
• 年：2016
• 卷：24
• 期：6
• 页码：977-987
• 全文大小：3368 K

文摘

<dl class="listitem" id="list_ulist0010"><dt class="label">•dt><dd>

d="p0010">A dynamic network allows LcαE7 to sample distinct conformational sub-states

dd><dt class="label">•dt><dd>

d="p0015">Related enzymes can evolve distinct dynamic networks around unique secondary structure

dd><dt class="label">•dt><dd>

d="p0020">Conformational flexibility facilitates promiscuous ligand binding and evolution

dd><dt class="label">•dt><dd>

d="p0025">Integrated kinetic/ensemble structural analyses can identify conformational sub-states

dd>dl>