Glycine transporter2 inhibitors: Getting the balance right

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• 作者：Robert J. Vandenberg ; ^{robert.vandenberg@sydney.edu.au" class="auth_mail" title="E-mail the corresponding author} ; Shannon N. Mostyn ; Jane E. Carland ; Renae M. Ryan
• 关键词：Glycine transport ; Glycine transport inhibitors ; Pain ; Glycine neurotransmission
• 刊名：Neurochemistry International
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：98
• 期：Complete
• 页码：89-93
• 全文大小：417 K

文摘

Neurotransmitter transporters are targets for a wide range of therapeutically useful drugs. This is because they have the capacity to selectively manipulate the dynamics of neurotransmitter concentrations and thereby enhance or diminish signalling through particular brain pathways. High affinity glycine transporters (GlyTs) regulate extracellular concentrations of glycine and provide novel therapeutic targets for neurological disorders.