Berberine protects against ischemia/reperfusion injury after orthotopic liver transplantation via activating Sirt1/FoxO3α induced autophagy

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• 作者：Yuanbang Lin^a ; ¹ ; Mingwei Sheng^b ; ¹ ; Yiqi Weng^b ; Rubin Xu^b ; Ning Lu^a ; Hongyin Du^b ; Wenli Yu^b ; ^{yuwenli999@sina.com}
• 关键词：Berberine ; Liver transplantation ; Sirtuin 1 ; Autophagy ; Apoptosis
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：5 February 2017
• 年：2017
• 卷：483
• 期：2
• 页码：885-891
• 全文大小：1910 K
• 卷排序：483

文摘

Berberine alleviated the histopathologic and functional damage of transplant liver. Liver transplantation inhibited the acetylation and activation of FoxO3α which was responsible for motivating the autophagic machinery. Berberine pretreatment reduced apoptotic cell death by enhancing Sirt1/FoxO3α induced autophagy.