Metformin improves semen characteristics of oligo-terato-asthenozoospermic men with metabolic syndrome

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• 作者：Giuseppe Morgante ; Claudia Tosti ; Raoul Orvieto ; Maria C. Musacchio ; Paola Piomboni ; Vincenzo De Leo
• 关键词：Metabolic syndrome ; metformin ; OTA ; semen ; testosterone
• 刊名：Fertility and Sterility
• 出版年：2011
• 出版时间：May 2011
• 年：2011
• 卷：95
• 期：6
• 页码：2150-2152
• 全文大小：73 K

文摘

To examine the appropriate treatment of oligo-terato-asthenozoospermic patients with metabolic syndrome, 45 patients were treated with metformin for 6 months. The use of metformin was associated with a statistically significant reduction in insulin resistance and sex hormone–binding globulin levels, a statistically significant increase in serum androgen levels, and a consequent improvement in semen characteristics.