The IL-6 family of cytokines modulates STAT3 activation by desumoylation of PML through SENP1 induction

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• 作者：Norihiko Ohbayashi ; Shiho Kawakami ; Ryuta Muromoto ; Sumihito Togi ; Osamu Ikeda ; Shinya Kamitani ; Yuichi Sekine ; Tsutomu Honjoh ; Tadashi Matsuda
• 关键词：IL-6 ; LIF ; SENP1 ; SUMO ; STAT3 ; PML ; Transcriptional regulation
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2008
• 出版时间：11 July 2008
• 年：2008
• 卷：371
• 期：4
• 页码：823-828
• 全文大小：788 K

文摘

Post-translational modification by small ubiquitin-like modifier (SUMO) plays an important role in the regulation of different signaling pathways and is involved in the formation of promyelocytic leukemia (PML) protein nuclear bodies following sumoylation of PML. In the present study, we found that IL-6 induces desumoylation of PML and dissociation between PML and SUMO1 in hepatoma cells. We also found that IL-6 induces mRNA expression of SENP1, a member of the SUMO-specific protease family. Furthermore, wild-type SENP1 but not an inactive SENP1 mutant restored the PML-mediated suppression of STAT3 activation. These results indicate that the IL-6 family of cytokines modulates STAT3 activation by desumoylation and inactivation PML through SENP1 induction.