Systemic administration of [6]-gingerol, a pungent constituent of ginger, induces hypothermia in rats via an inhibitory effect on metabolic rate

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• 作者：Shiori Ueki ; Michio Miyoshi ; Osamu Shido ; Junichi Hasegawa ; Tatsuo Watanabe
• 关键词：Body temperature ; Ginger ; Gingerol ; Heat-loss ; Metabolic rate
• 刊名：European Journal of Pharmacology
• 出版年：2008
• 出版时间：14 April 2008
• 年：2008
• 卷：584
• 期：1
• 页码：87-92
• 全文大小：615 K

文摘

We investigated the effects of systemic administrations of ginger (Zingiber officinale Roscoe, Zingiberaceae) or its pungent constituent, [6]-gingerol, on resting body temperature in rats. Rats given ginger-containing rat chow for 5 days showed no changes in their day–night cycle of body temperature or physical activity. However, a single intraperitoneal (i.p.) injection of [6]-gingerol (2.5 or 25 mg/kg) induced a rapid, marked drop in body temperature in a dose-related manner, with no change in physical activity. A significant decrease in metabolic rate was observed immediately after an i.p. injection of [6]-gingerol (25 mg/kg), although heat-loss responses underwent no alteration (versus vehicle). These results suggest that in rats: (a) a decrease in metabolic rate is responsible for the [6]-gingerol-induced hypothermia, and (b) [6]-gingerol modulates or interferes with the mechanisms underlying body temperature regulation, while other bioactive constituents of ginger may counteract the hypothermic effect of [6]-gingerol.