Synthesis and anti-HIV activity of nonatyrosine N- and O^1–9-decasulfate

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• 作者：Ueki ; Masaaki ; Watanabe ; Shigeru ; Ishii ; Yusuke ; Okunaka ; Osamu ; Uchino ; Keijiro ; Saitoh ; Takeshi ; et. al.
• 刊名：Bioorganic and Medicinal Chemistry
• 出版年：2001
• 出版时间：February, 2001
• 年：2001
• 卷：9
• 期：2
• 页码：477-486
• 全文大小：387 K

文摘

To develop a potent and effective anti-HIV compound with a definite polyanionic structure, synthesis of oligotyrosine sulfates by oligomerization with simultaneous sulfation of tyrosine was tried. One component was successfully isolated from the mixture containing many products as its sodium salt (Y-ART-4) and was identified as the salt of nonatyrosine N- and O^1–9-decasulfate, NaO₃S–[Tyr(SO₃Na)]₉–ONa. Anti-HIV activity of Y-ART-4, determined from the protection it provided against HIV-induced cytopathic effects, was almost the same with that of dextran sulfate and curdlan sulfate.