The Ag-39.9 at%Cu alloy reacts significantly with the CoSb3 substrate. The Ag-39.9 at%Cu/Ni (or Co or Ti) interfacial reactions at 450 °C are examined. The Ag-39.9 at%Cu/Ni (or Co or Ti) interfacial reactions at 600 °C are examined. Ag-39.9 at%Cu/Ti reaction rates are faster comparing those with Co and Ni. Co is a good barrier layer for the CoSb3 modules when Ag-Cu eutectic is used.