Optimization of a Production Process from the In vivo Response of a Diagnostical Drug

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• 作者：Kvå ; le ; Svein ; Dyrstad ; Knut ; Jacobsen ; Tove ; Asbj&oslash ; rnsen ; Odd A. ; Omtveit ; Tore
• 刊名：Computers and Chemical Engineering
• 出版年：1997
• 出版时间：1997
• 年：1997
• 卷：21
• 期：Supplement
• 页码：S343-S348
• 全文大小：405 K

文摘

A diagnostic drug's manufacture and use has been modeled and optimized. The optimization is performed by means of a total approach, i.e., the best combination of process parameters to give an adequate biologic (in vivo) response is determined. The examined drug is Infoson^TM, a new contrast agent for ultrasonographic imaging consisting of air-filled microspheres suspension with a thin shell of heat aggregated human albumin.