First-in-human safety and immunogenicity investigations of three adjuvanted reduced dose inactivated poliovirus vaccines (IPV-Al SSI) compared to full dose IPV Vaccine SSI when given as a booster vaccination to adolescents with a history of IPV vaccination at 3, 5, 12 months and 5 years of age
文摘
Three adjuvanted reduced dose IPV-Al SSI were safe and immunogenic in adolescents. The three IPV-Al SSI were highly immunogenic, but inferior to IPV Vaccine SSI as a booster. Reduced dose IPV-Al SSI is intended for markets in need of affordable IPV.