Sprague–Dawley rats selected and bred for “fast” or “slow” perforant path kindling.
After 15 generations “fast” rats were Perforant Path Kindling-Susceptible (PPKS).
After 15 generations “slow” rats were Perforant Path Kindling-Resistant (PPKR).
PPKS rats had increased open field activity and impaired hippocampal spatial memory.
Genetic background of PPKS/PPKR strains influences circuit plasticity and behavior.