Multi-functional lectin-like transcript-1: A new player in human immune regulation
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- 作者：Alba Llibrea ; alba.llibre@ndm.ox.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Paul Klenermana ; b ; Christian B Willberga ; b ; chris.willberg@ndm.ox.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 关键词：CRD ; carbohydrate recognition domain ; Clec ; C type lectin-like receptors ; CTLD ; C-type lectin-like domain ; Klr ; killer cell lectin-like receptor ; LLT1 ; lectin-like transcript 1 ; NKC ; natural killer gene complex ; OCIL ; osteoclast inhibitory lectin
- 刊名：Immunology Letters
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：177
- 期：Complete
- 页码：62-69
- 全文大小：1167 K
文摘
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LLT1 and CD161 are lectin–like receptors encoded within the NKC.
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LLT1 regulates NK cells, the germinal centre reaction and bone metabolism.
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CD161 is associated with NK cells and innate-like functions across T cell subsets.
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The expression of CD161 in tumours is associated with positive outcomes.