Effect of fibronectin adsorption on osteoblastic cellular responses to hydroxyapatite and alumina
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- 作者：Masakazu Kawashitaa ; m-kawa@ecei.tohoku.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Maki Hasegawaa ; Tada-aki Kudob ; Hiroyasu Kanetakab ; Toshiki Miyazakic ; Masami Hashimotod
- 关键词：Fibronectin ; MC3T3-E1 ; Hydroxyapatite ; Alumina
- 刊名：Materials Science & Engineering C
- 出版年：2016
- 出版时间：1 December 2016
- 年：2016
- 卷：69
- 期：Complete
- 页码：1268-1272
- 全文大小：834 K
文摘
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We studied osteoblast-like MC3T3-E1 cell responses on fibronectin (Fn)-coated discs (HAp/α-Al2O3).
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Fn adsorption enhanced adhesion and spreading of MC3T3-E1 cells on HAp but not on α-Al2O3.
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Fn adsorption hardly affected proliferation and differentiation of MC3T3-E1 cells on HAp and α-Al2O3.
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Fn adsorption might stimulate osteoconduction on HAp along with other serum proteins.