PLC-β1 and cell differentiation: An insight into myogenesis and osteogenesis

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• 作者：Giulia Ramazzotti^a ; ¹ ; ^{giulia.ramazzotti@unibo.it} ; Irene Faenza^a ; ¹ ; Roberta Fiume^a ; Anna Maria Billi^a ; Lucia Manzoli^a ; Sara Mongiorgi^a ; Stefano Ratti^a ; James A. McCubrey^b ; Pann-Ghill Suh^c ; Lucio Cocco^a ; Matilde Y. Follo^a
• 刊名：Advances in Biological Regulation
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：63
• 期：Complete
• 页码：1-5
• 全文大小：486 K
• 卷排序：63

文摘

Phosphoinositide-phospholipase C-β1 (PLC-β1) plays a crucial role in the initiation of the genetic program responsible for muscle differentiation and osteogenesis. During myogenic differentiation of murine C2C12 myoblasts, PLC-β1 signaling pathway involves the Inositol Polyphosphate Multikinase (IPMK) and β-catenin as downstream effectors. By means of c-jun binding to cyclin D3 promoter, the activation of PLC-β1 pathway determines cyclin D3 accumulation. However, osteogenesis requires PLC-β1 expression and up-regulation but it does not affect cyclin D3 levels, suggesting that the two processes require the activation of different mediators.