Three dimensional electrospun PCL/PLA blend nanofibrous scaffolds with significantly improved stem cells osteogenic differentiation and cranial bone formation

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• 作者：Qingqing Yao^a ; ¹ ; Jaqueline G.L. Cosme^b ; ^c ; ¹ ; Tao Xu^b ; Jacob M. Miszuk^a ; Paulo H.S. Picciani^c ; Hao Fong^b ; ^{Hao.Fong@sdsmt.edu} ; Hongli Sun^a ; ^{Hongli.Sun@usd.edu}
• 关键词：3D electrospun nanofibrous scaffold ; Polycaprolactone ; Polylactic acid ; Osteogenic differentiation ; Bone regeneration
• 刊名：Biomaterials
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：115
• 期：Complete
• 页码：115-127
• 全文大小：3934 K
• 卷排序：115

文摘

3D electrospun PCL/PLA blend nanofibrous scaffolds were developed. These scaffolds had high porosity and interconnected hierarchically structured pores. Both hMSCs osteogenic differentiation and cranial bone formation were improved. The scaffolds could act as favorable synthetic ECM for bone regeneration.