The CB subunit of crotoxin is a novel binding partner for CFTR.
CB binding to CFTR potentiates chloride channel current in normal and ∆ F508CFTR.
CB interaction with ∆ F508CFTR corrects its cellular localization defect.
A structural model of the CB/ΔF508CFTR binding interface is presented.
CB–CFTR interaction constitutes a novel target of therapeutic strategies in CF.