Transmembrane transport of steviol glucuronide and its potential interaction with selected drugs and natural compounds
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- 作者：Meiyu Wang1 ; Huixin Qi1 ; Jiajun Li ; Yunting Xu ; Hongjian Zhang ; zhanghongjian@suda.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Steviol glucuronide ; OAT3 ; Uptake transport ; Food-drug interaction
- 刊名：Food and Chemical Toxicology
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：86
- 期：Complete
- 页码：217-224
- 全文大小：983 K
文摘
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Steviol glucuronide (SVG) was the major metabolite of steviol, the aglycone of steviol glycosides.
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SVG was not a substrate of efflux transporters such as BCRP, MRP2, MATE1 and P-gp.
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Among uptake transporters, OAT3 played a predominant role in the cellular uptake of SVG.
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OTA3-mediated uptake of SVG was inhibited by quercetin, telmisartan, diclofenac, and mulberrin.
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Inhibition of OAT3 activity by drugs and natural compounds may alter SVG's renal clearance.