Ghrelin-mediated appetite regulation in the central nervous system

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• 作者：Katarzyna Kirsz ; Dorota A. Zieba  ; ;   ; ^{rzzieba@cyf-kr.edu.pl} ;   ; ^{dorota39@tlen.pl}
• 关键词：Ghrelin ; Central nervous system ; Metabolism ; Biological rhythm
• 刊名：Peptides
• 出版年：2011
• 出版时间：November 2011
• 年：2011
• 卷：32
• 期：11
• 页码：2256-2264
• 全文大小：616 K

文摘

The gut hormone and neuropeptide ghrelin was initially identified in the periphery as a compound released in the bloodstream in response to a negative energetic status. In the central nervous system (CNS), ghrelin mainly acts on the hypothalamus and the limbic system, with its best-known biological role being the regulation of appetitive functions. Recent research has shown that ghrelin is not an indispensable factor in the regulation of food intake. However, it plays a key role in the metabolic changes of lipids, mainly those involving hypothalamic NOS, AMPK, CaMKK2, CPT1 and UCP2 proteins. Ghrelin participates in the regulation of memory processes and the feeling of pleasure resulting from eating, both of which are metabolism-dependent and may be essential for the successful achievement of adaptive appetitive behavior. Ghrelin exerts its biological effect through a complicated network of neuroendocrine links, including the melanocortin and endocannabinoid systems. The activity of ghrelin is connected with circadian and annual fluctuations, which depend on seasons and food availability.